Publications

Selected Publications by our Researchers

The Bioenergetic Health Index: a new concept in mitochondrial translational research

Balu K. Chacko, Philip A. Kramer, Saranya Ravi, Gloria A. Benavides, Tanecia Mitchell, Brian P. Dranka, David Ferrick, Ashwani K. Singal, Scott W. Ballinger, Shannon M. Bailey, Robert W. Hardy, Jianhua Zhang, Degui Zhi, Victor M. Darley-Usmar
Clin Sci (Lond) 2014 Sep 1; 127 (Pt 6): 367 373.

A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers

Philip A. Kramer, Saranya Ravi, Balu Chacko, Michelle S. Johnson, Victor M. Darley-Usmar
Redox Biol. 2014; 2: 206 210. Published online 2014 Jan 10. doi: 10.1016/j.redox.2013.12.026

Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health

Daniel J. Tyrrell, Manish S. Bharadwaj, Matthew J. Jorgensen, Thomas C. Register, Anthony J.A. Molina
Redox Biol. 2016 Dec; 10: 65 77.

Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients

Philip A. Kramer, Balu K. Chacko, David J. George, Degui Zhi, Chih-Cheng Wei, Louis J. Dell’Italia, Spencer J. Melby, James F. George, Victor M. Darley-Usmar
Biosci Rep. 2015 Aug; 35(4): e00237.

Defining the effects of storage on platelet bioenergetics; the role of increased proton leak

Saranya Ravi, Balu Chacko, Philip A. Kramer, Hirotaka Sawada, Michelle S. Johnson, Degui Zhi, Marisa B. Marques, Victor M. Darley-Usmar
Biochim Biophys Acta. 2015 Nov; 1852(11): 2525 2534.

Modification of Platelet Proteins by 4-hydroxynonenal: Potential Mechanisms for Inhibition of Aggregation and Metabolism

Saranya Ravi, Michelle S. Johnson, Balu K. Chacko, Philip A. Kramer, Hirotaka Sawada, Morgan L. Locy, Landon. S. Wilson, Stephen Barnes, Marisa B. Marques, Victor M. Darley-Usmar
Free Radic Biol Med.

Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women

Amanda L. Willig, Philip A. Kramer, Balu K. Chacko, Victor M. Darley-Usmar, Sonya L. Heath, E. Turner Overton
Redox Biol. 2017 Aug; 12: 648 656.

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

Gargi Mahapatra, S. Carrie Smith, Timothy M. Hughes, Benjamin Wagner, Joseph A. Maldjian, Barry I. Freedman, Anthony J. A. Molina
Clin Sci (Lond)?2018 Dec 12; 132(23): 2509 2518.

Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood

Balu K Chacko, Philip A Kramer, Saranya Ravi, Michelle S Johnson, Robert W Hardy, Scott W Ballinger, Victor M Darley-Usmar
Lab Invest.?2013 Jun;?93(6): 690?700.?Published online 2013 Mar 25.?doi:?10.1038/labinvest.2013.53

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

Sameer Kalghatgi, Catherine S. Spina, James C. Costello, Marc Liesa, J Ruben Morones-Ramirez, Shimyn Slomovic, Anthony Molina, Orian S. Shirihai, James J. Collins
Sci Transl Med.

Blood-Cell Bioenergetics are Associated With Physical Function and Inflammation in Overweight/Obese Older Adults

Daniel J. Tyrrell, Manish S. Bharadwaj, Cynthia G. Van Horn, Anthony P. Marsh, Barbara J. Nicklas, Anthony J.A. Molina
Exp Gerontol. 2015 Oct; 70: 84 91.

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

Daniel J. Tyrrell, Manish S. Bharadwaj, Matthew J. Jorgensen, Thomas C. Register, Carol Shively, Rachel N. Andrews, Bryan Neth, C. Dirk Keene, Akiva Mintz, Suzanne Craft, Anthony J. A. Molina
Oxid Med Cell Longev. 2017; 2017: 7317251. 

Skeletal Muscle Mitochondrial Respiration Is Elevated in Female Cynomolgus Macaques Fed a Western Compared with a Mediterranean Diet

Jenny L Gonzalez-Armenta, Zhengrong Gao, Susan E Appt, Mara Z Vitolins, Kristofer T Michalson, Thomas C Register, Carol A Shively, Anthony J. A. Molina
The Journal of Nutrition, Volume 149, Issue 9, September 2019, Pages 1493 1502,

Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F

Geeta Datta, Philip A. Kramer, Michelle S. Johnson, Hirotaka Sawada, Lesley E. Smythies, David K. Crossman, Balu Chacko, Scott W. Ballinger, David G. Westbrook, Palgunachari Mayakonda, G. M. Anantharamaiah, Victor M. Darley-Usmar, C. Roger White
Biochem J.

Metabolic Plasticity in Resting and Thrombin Activated Platelets

Saranya Ravi, Balu Chacko, Hirotaka Sawada, Philip A. Kramer, Michelle S. Johnson, Gloria A. Benavides, Valerie O?Donnell, Marisa B. Marques, Victor M. Darley-Usmar
PLoS One. 2015; 10(4): e0123597.

Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults

Manish S. Bharadwaj, Daniel J. Tyrrell, Iris Leng, Jamehl L. Demons, Mary F. Lyles, J. Jeffrey Carr, Barbara J. Nicklas, Anthony J. A. Molina
BMC Obes. 2015; 2: 40.

Inhibition of the lymphocyte metabolic switch by the oxidative burst of human neutrophils

Philip A. Kramer, Lynn Prichard, Balu Chacko, Saranya Ravi, E. Turner Overton, Sonya L. Heath, Victor Darley-Usmar
Clin Sci (Lond) Author manuscript; available in PMC 2017 Sep 25.

Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults

Daniel J. Tyrrell, Manish S. Bharadwaj, Cynthia G. Van Horn, Stephen B. Kritchevsky, Barbara J. Nicklas, Anthony J. A. Molina
J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11): 1394 1399.

Bioenergetics and the Oxidative Burst: Protocols for the Isolation and Evaluation of Human Leukocytes and Platelets

Philip A. Kramer, Balu K. Chacko, Saranya Ravi, Michelle S. Johnson, Tanecia Mitchell, Victor M. Darley-Usmar
J Vis Exp. 2014; (85): 51301. Published online 2014 Mar 27. doi: 10.3791/51301

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